What the FDA labels say about taking them together
Erythromycin and estradiol
Estradiol's FDA label of April 3, 2024 names erythromycin in its drug interactions section; the erythromycin labels PlainMeds reads (4) do not name estradiol. The estradiol label: “Inhibitors of CYP3A4, such as erythromycin, clarithromycin, ketoconazole, itraconazole, ritonavir, and grapefruit juice, may increase plasma concentrations of estrogens and result in adverse reactions.”
Check it at the source: the erythromycin FDA label on DailyMed (effective August 1, 2024, Teva Pharmaceuticals USA, Inc.); the estradiol FDA label on DailyMed (effective April 3, 2024, Amneal Pharmaceuticals LLC).
What does the erythromycin label say about estradiol?
Erythromycin's label (effective August 1, 2024) and its 3 other brand-application labels do not name estradiol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Erythromycin), Teva Pharmaceuticals USA, Inc., effective August 1, 2024 (SPL set 75a0bd5a-d09f-483b-bfd8-f8343b149eb2), via openFDA; the full label on DailyMed
What does the estradiol label say about erythromycin?
Estradiol label, drug interactionsInhibitors of CYP3A4 such as erythromycin, clarithromycin, ketoconazole, itraconazole, ritonavir and grapefruit juice may increase plasma concentrations of estrogens and may result in adverse reactions.
Source: FDA drug label (Divigel, NDA022038), Vertical Pharmaceuticals, LLC, effective February 27, 2026 (SPL set 59e610dc-883e-4f07-9ec6-a5841b0bf9fb), via openFDA
Source: FDA drug label (YUVAFEM), Amneal Pharmaceuticals LLC, effective April 3, 2024 (SPL set 30c7f6ba-7a9e-4853-b3e4-e00a46560224), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Erythromycin | Estradiol | |
|---|---|---|
| Labeled for | Bacterial infections, Acne | Menopause symptoms, Breast cancer, Osteoporosis |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $1.96 per tablet 250 mg tablet | $0.0635 per tablet 1 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once