What the FDA labels say about taking them together
Ergotamine and posaconazole
Posaconazole's FDA label of August 3, 2026 names ergotamine in its contraindications section; the ergotamine label PlainMeds reads does not name posaconazole. The posaconazole label: “Noxafil may increase the plasma concentrations of ergot alkaloids which may lead to ergotism.”
Check it at the source: the ergotamine FDA label on DailyMed (effective February 25, 2025, Pangea Pharmaceuticals LLC); the posaconazole FDA label on DailyMed (effective August 3, 2026, Aurobindo Pharma Limited).
What does the ergotamine label say about posaconazole?
Ergotamine's label (effective February 25, 2025) does not name posaconazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Ergomar Sublingual), Pangea Pharmaceuticals LLC, effective February 25, 2025 (SPL set a9582fdb-7ddd-4f69-aa7a-66247cdb8c92), via openFDA; the full label on DailyMed
What does the posaconazole label say about ergotamine?
Posaconazole label, contraindicationsPosaconazole delayed-release tablets may increase the plasma concentrations of ergot alkaloids (ergotamine and dihydroergotamine) which may lead to ergotism [see Drug Interactions (7.2) ].
Source: FDA drug label (Noxafil, NDA022003), Merck Sharp & Dohme LLC, effective February 13, 2026 (SPL set b073b082-7b57-4423-8c06-4fd4263d6f84), via openFDA
Source: FDA drug label (POSACONAZOLE), Aurobindo Pharma Limited, effective August 3, 2026 (SPL set f8a26673-261c-4e8e-b1e1-9e23aaf7f285), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ergotamine | Posaconazole | |
|---|---|---|
| Labeled for | n/a | Fungal infections |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $43.46 per tablet 2 mg tablet sublingual | $2.03 per tablet 100 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once