What the FDA labels say about taking them together
Ergotamine and nitroglycerin
Nitroglycerin's FDA label of February 15, 2023 names ergotamine in its drug interactions section; the ergotamine label PlainMeds reads does not name nitroglycerin. The nitroglycerin label: “Monitor APTT. Ergotamine: increased bioavailability of ergotamine.”
Check it at the source: the ergotamine FDA label on DailyMed (effective February 25, 2025, Pangea Pharmaceuticals LLC); the nitroglycerin FDA label on DailyMed (effective February 15, 2023, Viatris Specialty LLC).
What does the ergotamine label say about nitroglycerin?
Ergotamine's label (effective February 25, 2025) does not name nitroglycerin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Ergomar Sublingual), Pangea Pharmaceuticals LLC, effective February 25, 2025 (SPL set a9582fdb-7ddd-4f69-aa7a-66247cdb8c92), via openFDA; the full label on DailyMed
What does the nitroglycerin label say about ergotamine?
Nitroglycerin label, drug interactionsDRUG INTERACTIONS Ergotamine: increased bioavailability of ergotamine.
Source: FDA drug label (Rectiv, NDA021359), Allergan, Inc., effective September 8, 2026 (SPL set 603aa9ed-54c4-4a35-ade4-690fa44850e4), via openFDA
Source: FDA drug label (Nitrostat), Viatris Specialty LLC, effective February 15, 2023 (SPL set 9a52da75-d0af-4237-96c0-0b12adfa8636), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ergotamine | Nitroglycerin | |
|---|---|---|
| Labeled for | n/a | Angina, High blood pressure, Heart failure, Heart attack and coronary artery disease |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $43.46 per tablet 2 mg tablet sublingual | $0.127 per tablet 0.4 mg tablet sl |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once