What the FDA labels say about taking them together
Ergotamine and lenacapavir
Lenacapavir's FDA label of August 27, 2026 names ergotamine in its drug interactions section; the ergotamine label PlainMeds reads does not name lenacapavir. The lenacapavir label: “Concomitant administration of SUNLENCA with dihydroergotamine, ergotamine or methylergonovine is not recommended.”
Check it at the source: the ergotamine FDA label on DailyMed (effective February 25, 2025, Pangea Pharmaceuticals LLC); the lenacapavir FDA label on DailyMed (effective August 27, 2026, Gilead Sciences, Inc.).
What does the ergotamine label say about lenacapavir?
Ergotamine's label (effective February 25, 2025) does not name lenacapavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Ergomar Sublingual), Pangea Pharmaceuticals LLC, effective February 25, 2025 (SPL set a9582fdb-7ddd-4f69-aa7a-66247cdb8c92), via openFDA; the full label on DailyMed
What does the lenacapavir label say about ergotamine?
Lenacapavir label, drug interactionsConcomitant Drug Class/Drug Name: Ergot derivatives: dihydroergotamine ergotamine methylergonovine; Effect on Concentration ↑ = Increase, ↓ = Decrease.: ↑ dihydroergotamine ↑ ergotamine ↑ methylergonovine; Clinical Comment: Concomitant administration of SUNLENCA with dihydroergotamine, ergotamine or methylergonovine is not recommended.
Source: FDA drug label (Sunlenca), Gilead Sciences, Inc., effective August 27, 2026 (SPL set e5652804-29c4-40d7-aeb2-0142ed2a7b5b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ergotamine | Lenacapavir | |
|---|---|---|
| Labeled for | n/a | HIV |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $43.46 per tablet 2 mg tablet sublingual | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once