What the FDA labels say about taking them together
Ergotamine and fosamprenavir
Fosamprenavir's FDA label of September 15, 2023 names ergotamine in its contraindications section; the ergotamine label PlainMeds reads does not name fosamprenavir. The fosamprenavir label: “Coadministration is contraindicated due to potential for serious and/or life-threatening reactions such as acute ergot toxicity characterized by peripheral vasospasm and ischemia of the extremities and other tissues.”
Check it at the source: the ergotamine FDA label on DailyMed (effective February 25, 2025, Pangea Pharmaceuticals LLC); the fosamprenavir FDA label on DailyMed (effective September 15, 2023, Mylan Pharmaceuticals Inc.).
What does the ergotamine label say about fosamprenavir?
Ergotamine's label (effective February 25, 2025) does not name fosamprenavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Ergomar Sublingual), Pangea Pharmaceuticals LLC, effective February 25, 2025 (SPL set a9582fdb-7ddd-4f69-aa7a-66247cdb8c92), via openFDA; the full label on DailyMed
What does the fosamprenavir label say about ergotamine?
Fosamprenavir label, contraindicationsRifampin o Antipsychotic: Lurasidone (with ritonavir ), pimozide o Ergot derivatives: Dihydroergotamine, ergonovine, ergotamine, methylergonovine o GI motility agent:
Fosamprenavir label, drug interactionsConcomitant Drug Class/Drug Name: Ergot derivatives: Dihydroergotamine, ergonovine, ergotamine, methylergonovine; Effect on Concentration of Amprenavir or Concomitant Drug: ↑ Ergot derivatives; Clinical Comment: Coadministration is contraindicated due to potential for serious and/or life-threatening reactions such as acute ergot toxicity characterized by peripheral vasospasm and ischemia of the extremities and other tissues [see ].
Source: FDA drug label (Fosamprenavir Calcium), Mylan Pharmaceuticals Inc., effective September 15, 2023 (SPL set 3a1424d8-844c-4e24-9ebd-b2c2b61b61a3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ergotamine | Fosamprenavir | |
|---|---|---|
| Labeled for | n/a | HIV |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $43.46 per tablet 2 mg tablet sublingual | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once