What the FDA labels say about taking them together
Epirubicin and trastuzumab
Epirubicin's FDA label of July 24, 2026 names trastuzumab in its drug interactions section, and trastuzumab's label names epirubicin too. The epirubicin label: “Patients receiving ELLENCE after stopping treatment with other cardiotoxic drugs, especially those with long half-lives such as trastuzumab, may be at increased risk of developing cardiotoxicity.”
Check it at the source: the epirubicin FDA label on DailyMed (effective July 24, 2026, Pharmacia & Upjohn Company LLC); the trastuzumab FDA label on DailyMed (effective May 29, 2026, Genentech, Inc.).
What does the epirubicin label say about trastuzumab?
Epirubicin label, drug interactionsPatients receiving ELLENCE after stopping treatment with other cardiotoxic agents, especially those with long half-lives such as trastuzumab, may be at an increased risk of developing cardiotoxicity [see Dosage and Administration (2) and Warnings and Precautions (5.1) ].
Source: FDA drug label (Ellence), NDA050778 (Pfizer Inc), as published by Pharmacia & Upjohn Company LLC, effective July 24, 2026 (SPL set 0a03c798-a652-4895-b29c-3b521a89ba42), via openFDA; the full label on DailyMed
What does the trastuzumab label say about epirubicin?
Trastuzumab label, warnings and precautionsH0648g (AC) Anthracycline (doxorubicin or epirubicin) and cyclophosphamide.; Cardiac Dysfunction; 28%; 7%; 19%; 3%
Source: FDA drug label (Ogivri, BLA761074), Mylan Institutional LLC, effective February 8, 2021 (SPL set 6b7938e6-14c7-4a65-9605-967542ecfb8f), via openFDA
Source: FDA drug label (Herceptin), Genentech, Inc., effective May 29, 2026 (SPL set 492dbdb2-077e-4064-bff3-372d6af0a7a2), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Epirubicin | Trastuzumab | |
|---|---|---|
| Labeled for | n/a | Breast cancer |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once