What the FDA labels say about taking them together
Epinephrine and sevoflurane
Sevoflurane's FDA label of February 12, 2025 names epinephrine in its drug interactions section; the epinephrine labels PlainMeds reads (4) do not name sevoflurane. The sevoflurane label: “Epinephrine Epinephrine administered with sevoflurane may increase the risk of ventricular arrhythmias.”
Check it at the source: the epinephrine FDA label on DailyMed (effective July 13, 2026, A-S Medication Solutions); the sevoflurane FDA label on DailyMed (effective February 12, 2025, AbbVie Inc.).
What does the epinephrine label say about sevoflurane?
Epinephrine's label (effective July 13, 2026) and its 3 other brand-application labels do not name sevoflurane in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Epinephrine), A-S Medication Solutions, effective July 13, 2026 (SPL set 6e811e28-0199-4df7-a916-5940c632401d), via openFDA; the full label on DailyMed
What does the sevoflurane label say about epinephrine?
Sevoflurane label, drug interactionsEpinephrine Epinephrine administered with sevoflurane may increase the risk of ventricular arrhythmias.
Sevoflurane label, warningsIn most cases, bradycardia improved with decreasing the concentration of sevoflurane, manipulating the airway, or administering an anticholinergic or epinephrine.
Source: FDA drug label (Ultane), AbbVie Inc., effective February 12, 2025 (SPL set c9aa6489-5a36-44ed-9512-b996833d82f7), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Epinephrine | Sevoflurane | |
|---|---|---|
| Labeled for | Asthma | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $123.51 per unit 0.15 mg auto-injct | n/a |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once