What the FDA labels say about taking them together
Epinephrine and phenoxybenzamine
Phenoxybenzamine's FDA label of July 3, 2026 names epinephrine in its drug interactions section; the epinephrine labels PlainMeds reads (4) do not name phenoxybenzamine.
Check it at the source: the epinephrine FDA label on DailyMed (effective July 13, 2026, A-S Medication Solutions); the phenoxybenzamine FDA label on DailyMed (effective July 3, 2026, Amneal Pharmaceuticals NY LLC).
What does the epinephrine label say about phenoxybenzamine?
Epinephrine's label (effective July 13, 2026) and its 3 other brand-application labels do not name phenoxybenzamine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Epinephrine), A-S Medication Solutions, effective July 13, 2026 (SPL set 6e811e28-0199-4df7-a916-5940c632401d), via openFDA; the full label on DailyMed
What does the phenoxybenzamine label say about epinephrine?
Phenoxybenzamine label, drug interactionsDrug Interactions 2 – Phenoxybenzamine hydrochloride may interact with compounds that stimulate both alpha- and beta- adrenergic receptors (i.e. epinephrine) to produce an exaggerated hypotensive response and tachycardia (see WARNING ).
Source: FDA drug label (Phenoxybenzamine hydrochloride), Amneal Pharmaceuticals NY LLC, effective July 3, 2026 (SPL set 0be6a394-cd10-42fc-97cf-ad53d81d8d93), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Epinephrine | Phenoxybenzamine | |
|---|---|---|
| Labeled for | Asthma | High blood pressure |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $123.51 per unit 0.15 mg auto-injct | n/a |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once