What the FDA labels say about taking them together
Epinephrine and perphenazine
Perphenazine's FDA label of December 12, 2024 names epinephrine in its warnings section; epinephrine's label does not name perphenazine itself but warns about its class (phenothiazines). The perphenazine label: “If hypotension develops, epinephrine should not be administered since its action is blocked and partially reversed by perphenazine.”
Check it at the source: the epinephrine FDA label on DailyMed (effective July 13, 2026, A-S Medication Solutions); the perphenazine FDA label on DailyMed (effective December 12, 2024, Rising Pharma Holdings, Inc.).
What does the epinephrine label say about perphenazine?
Epinephrine's label does not name perphenazine itself; it warns about its class (phenothiazines):
Epinephrine label, drug interactionsDrugs Antagonizing Pressor Effects of Epinephrine α-blockers, such as phentolamine Vasodilators, such as nitrates Diuretics Antihypertensives Ergot alkaloids Phenothiazine antipsychotics 7.2.
Source: FDA drug label (Epinephrine), A-S Medication Solutions, effective July 13, 2026 (SPL set 6e811e28-0199-4df7-a916-5940c632401d), via openFDA; the full label on DailyMed
What does the perphenazine label say about epinephrine?
Perphenazine label, warningsIf hypotension develops, epinephrine should not be administered since its action is blocked and partially reversed by perphenazine.
Source: FDA drug label (PERPHENAZINE), Rising Pharma Holdings, Inc., effective December 12, 2024 (SPL set 0ebf4c11-1810-42f6-a8e3-071616e33d5d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Epinephrine | Perphenazine | |
|---|---|---|
| Labeled for | Asthma | Schizophrenia, Nausea and vomiting |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $123.51 per unit 0.15 mg auto-injct | $0.161 per tablet 4 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once