What the FDA labels say about taking them together
Epinephrine and pegaspargase
Pegaspargase's FDA label of October 7, 2024 names epinephrine in its warnings and precautions section; the epinephrine labels PlainMeds reads (4) do not name pegaspargase. The pegaspargase label: “Observe patients for 1 hour after administration of ONCASPAR in a setting with resuscitation equipment and other agents necessary to treat anaphylaxis.”
Check it at the source: the epinephrine FDA label on DailyMed (effective July 13, 2026, A-S Medication Solutions); the pegaspargase FDA label on DailyMed (effective October 7, 2024, Servier Pharmaceuticals LLC).
What does the epinephrine label say about pegaspargase?
Epinephrine's label (effective July 13, 2026) and its 3 other brand-application labels do not name pegaspargase in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Epinephrine), A-S Medication Solutions, effective July 13, 2026 (SPL set 6e811e28-0199-4df7-a916-5940c632401d), via openFDA; the full label on DailyMed
What does the pegaspargase label say about epinephrine?
Pegaspargase label, warnings and precautionsObserve patients for 1 hour after administration of ONCASPAR in a setting with resuscitation equipment and other agents necessary to treat anaphylaxis (for example, epinephrine, oxygen, intravenous steroids, antihistamines) [see Dosage and Administration (2.4) ].
Source: FDA drug label (ONCASPAR), BLA103411 (Sigma Tau), as published by Servier Pharmaceuticals LLC, effective October 7, 2024 (SPL set ac7b6a6f-6ddb-48c6-8088-d8a8e3fea6ce), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Epinephrine | Pegaspargase | |
|---|---|---|
| Labeled for | Asthma | Leukemia, lymphoma and myeloma |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $123.51 per unit 0.15 mg auto-injct | n/a |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once