What the FDA labels say about taking them together
Epinephrine and opicapone
Opicapone's FDA label of October 15, 2025 names epinephrine in its warnings and precautions section; the epinephrine labels PlainMeds reads (4) do not name opicapone. The opicapone label: “Effects with Concomitant Use of Drugs Metabol ized by Catechol-O-Methyltransferase (COMT) Possible arrhythmias, increased heart rate, and excessive changes in blood pressure may occur with concomitant use of ONGENTYS …”
Check it at the source: the epinephrine FDA label on DailyMed (effective July 13, 2026, A-S Medication Solutions); the opicapone FDA label on DailyMed (effective October 15, 2025, Amneal Pharmaceuticals LLC).
What does the epinephrine label say about opicapone?
Epinephrine's label (effective July 13, 2026) and its 3 other brand-application labels do not name opicapone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Epinephrine), A-S Medication Solutions, effective July 13, 2026 (SPL set 6e811e28-0199-4df7-a916-5940c632401d), via openFDA; the full label on DailyMed
What does the opicapone label say about epinephrine?
Opicapone label, warnings and precautionsEffects with Concomitant Use of Drugs Metabol ized by Catechol-O-Methyltransferase (COMT) Possible arrhythmias, increased heart rate, and excessive changes in blood pressure may occur with concomitant use of ONGENTYS and drugs metabolized by COMT (e.g., isoproterenol, epinephrine, norepinephrine, dopamine, and dobutamine), regardless of the route of administration (including inhalation).
Source: FDA drug label (ONGENTYS), Amneal Pharmaceuticals LLC, effective October 15, 2025 (SPL set a511a531-112e-43f8-a43f-5334b0efe979), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Epinephrine | Opicapone | |
|---|---|---|
| Labeled for | Asthma | Parkinson's disease |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $123.51 per unit 0.15 mg auto-injct | $24.67 per capsule 25 mg capsule |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once