What the FDA labels say about taking them together
Epinephrine and milnacipran
Milnacipran's FDA label of September 10, 2025 names epinephrine in its drug interactions section; the epinephrine labels PlainMeds reads (4) do not name milnacipran.
Check it at the source: the epinephrine FDA label on DailyMed (effective July 13, 2026, A-S Medication Solutions); the milnacipran FDA label on DailyMed (effective September 10, 2025, Allergan, Inc.).
What does the epinephrine label say about milnacipran?
Epinephrine's label (effective July 13, 2026) and its 3 other brand-application labels do not name milnacipran in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Epinephrine), A-S Medication Solutions, effective July 13, 2026 (SPL set 6e811e28-0199-4df7-a916-5940c632401d), via openFDA; the full label on DailyMed
What does the milnacipran label say about epinephrine?
Milnacipran label, drug interactionsTherefore, concomitant use of SAVELLA with epinephrine and norepinephrine may be associated with paroxysmal hypertension and possible arrhythmia [see Warnings and Precautions ( 5.3 , 5.4 )].
Source: FDA drug label (Savella), NDA022256 (Abbvie), as published by Allergan, Inc., effective September 10, 2025 (SPL set 16a4a314-f97e-4e91-95e9-576a3773d284), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Epinephrine | Milnacipran | |
|---|---|---|
| Labeled for | Asthma | Nerve pain and fibromyalgia |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $123.51 per unit 0.15 mg auto-injct | $2.82 per tablet 100 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once