What the FDA labels say about taking them together
Epinephrine and levalbuterol
Levalbuterol's FDA label of December 10, 2025 names epinephrine in its drug interactions section; the epinephrine labels PlainMeds reads (4) do not name levalbuterol. The levalbuterol label: “02/2020 7.1 Short-Acting Bronchodilators Avoid concomitant use of other short-acting sympathomimetic bronchodilators or epinephrine in patients being treated with Levalbuterol Inhalation Solution, USP.”
Check it at the source: the epinephrine FDA label on DailyMed (effective July 13, 2026, A-S Medication Solutions); the levalbuterol FDA label on DailyMed (effective December 10, 2025, Ritedose Pharmaceuticals, LLC).
What does the epinephrine label say about levalbuterol?
Epinephrine's label (effective July 13, 2026) and its 3 other brand-application labels do not name levalbuterol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Epinephrine), A-S Medication Solutions, effective July 13, 2026 (SPL set 6e811e28-0199-4df7-a916-5940c632401d), via openFDA; the full label on DailyMed
What does the levalbuterol label say about epinephrine?
Levalbuterol label, drug interactions02/2020 7.1 Short-Acting Bronchodilators Avoid concomitant use of other short-acting sympathomimetic bronchodilators or epinephrine in patients being treated with Levalbuterol Inhalation Solution, USP.
Xopenex Hfa label (Lupin Pharmaceuticals, Inc., June 2, 2025), drug interactionsDRUG INTERACTIONS Other short-acting sympathomimetic aerosol bronchodilators or epinephrine should not be used concomitantly with XOPENEX HFA.
Source: FDA drug label (Xopenex Hfa, NDA021730), Lupin Pharmaceuticals, Inc., effective June 2, 2025 (SPL set 70a35706-d7a8-4a48-98c6-1cab1c42fe8d), via openFDA
Source: FDA drug label (Levalbuterol), Ritedose Pharmaceuticals, LLC, effective December 10, 2025 (SPL set d6998949-e1cb-4c86-a480-c0dfd9cb75b5), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Epinephrine | Levalbuterol | |
|---|---|---|
| Labeled for | Asthma | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $123.51 per unit 0.15 mg auto-injct | $0.262 per mL 0.31 mg/3 mL solution |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once