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What the FDA labels say about taking them together

Epinephrine and laronidase

Laronidase's FDA label of July 22, 2026 names epinephrine in its warnings and precautions section; the epinephrine labels PlainMeds reads (4) do not name laronidase. The laronidase label: “Exercise caution if epinephrine is being considered for use in patients with MPS I due to the increased prevalence of coronary artery disease in these patients.”

Check it at the source: the epinephrine FDA label on DailyMed (effective July 13, 2026, A-S Medication Solutions); the laronidase FDA label on DailyMed (effective July 22, 2026, Genzyme Corporation).

What does the epinephrine label say about laronidase?

Epinephrine's label (effective July 13, 2026) and its 3 other brand-application labels do not name laronidase in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Epinephrine), A-S Medication Solutions, effective July 13, 2026 (SPL set 6e811e28-0199-4df7-a916-5940c632401d), via openFDA; the full label on DailyMed

What does the laronidase label say about epinephrine?

Laronidase label, warnings and precautions

Exercise caution if epinephrine is being considered for use in patients with MPS I due to the increased prevalence of coronary artery disease in these patients.

Source: FDA drug label (ALDURAZYME), BLA125058 (Biomarin), as published by Genzyme Corporation, effective July 22, 2026 (SPL set a80ac249-cae4-41f3-88bb-344088b20e60), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

16Epinephrine generic labelers
0Laronidase generic labelers
EpinephrineLaronidase
Labeled forAsthman/a
Boxed warningNoYes
Pharmacy cost (NADAC)$123.51 per unit 0.15 mg auto-injctn/a
Shortage nowA presentation being discontinuedNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?