What the FDA labels say about taking them together
Epinephrine and isocarboxazid
Isocarboxazid's FDA label of April 21, 2026 names epinephrine in its contraindications section; epinephrine's label does not name isocarboxazid itself but warns about its class (MAO inhibitors).
Check it at the source: the epinephrine FDA label on DailyMed (effective July 13, 2026, A-S Medication Solutions); the isocarboxazid FDA label on DailyMed (effective April 21, 2026, Lifsa Drugs LLC).
What does the epinephrine label say about isocarboxazid?
Epinephrine's label does not name isocarboxazid itself; it warns about its class (MAO inhibitors):
Epinephrine label, drug interactionsDRUG INTERACTIONS Drugs that counter the pressor effects of epinephrine include alpha blockers, vasodilators such as nitrates, diuretics, antihypertensives, and ergot alkaloids. ( 7 .1) Drugs that potentiate the effects of epinephrine include sympathomimetics, beta blockers, tricyclic antidepressants, MAO inhibitors, COMT inhibitors, clonidine, doxapram, oxytocin, levothyroxine sodium, and certain antihistamines. …
Epinephrine label, warnings and precautionsPatients receiving monoamine oxidase inhibitors (MAOI) or antidepressants of triptyline or imipramine types may experience severe, prolonged hypertension when given epinephrine.
Source: FDA drug label (Epinephrine), A-S Medication Solutions, effective July 13, 2026 (SPL set 6e811e28-0199-4df7-a916-5940c632401d), via openFDA; the full label on DailyMed
What does the isocarboxazid label say about epinephrine?
Isocarboxazid label, contraindicationsUse of sympathomimetics and compounds such as guanethidine, methyldopa, methylphenidate, reserpine, epinephrine, norepinephrine, phenylalanine, dopamine, levodopa, tyrosine, and tryptophan with Marplan may precipitate hypertension, headache, and related symptoms.
Source: FDA drug label (MARPLAN), Lifsa Drugs LLC, effective April 21, 2026 (SPL set 95fde749-44ad-4668-86c4-0ff17bca0074), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Epinephrine | Isocarboxazid | |
|---|---|---|
| Labeled for | Asthma | Depression |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $123.51 per unit 0.15 mg auto-injct | n/a |
| Shortage now | A presentation being discontinued | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once