What the FDA labels say about taking them together
Epinephrine and imiglucerase
Imiglucerase's FDA label of August 27, 2026 names epinephrine in its boxed warning section; the epinephrine labels PlainMeds reads (4) do not name imiglucerase. The imiglucerase label: “… and immediately initiate appropriate medical treatment, including use of epinephrine.”
Check it at the source: the epinephrine FDA label on DailyMed (effective July 13, 2026, A-S Medication Solutions); the imiglucerase FDA label on DailyMed (effective August 27, 2026, Genzyme Corporation).
What does the epinephrine label say about imiglucerase?
Epinephrine's label (effective July 13, 2026) and its 3 other brand-application labels do not name imiglucerase in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Epinephrine), A-S Medication Solutions, effective July 13, 2026 (SPL set 6e811e28-0199-4df7-a916-5940c632401d), via openFDA; the full label on DailyMed
What does the imiglucerase label say about epinephrine?
Imiglucerase label, boxed warningAnaphylaxis has occurred during the early course of enzyme replacement therapy and after extended duration of therapy. ( 5.1 ) Initiate CEREZYME in a healthcare setting with appropriate medical monitoring and support measures, including access to cardiopulmonary resuscitation equipment. ( 5.1 ) If a severe hypersensitivity reaction (e.g., anaphylaxis) occurs, discontinue CEREZYME and immediately initiate appropriate medical treatment, including use of epinephrine.
Imiglucerase label, warnings and precautionsIf a severe hypersensitivity reaction (e.g., anaphylaxis) occurs, discontinue CEREZYME and immediately initiate appropriate medical treatment, including use of epinephrine.
Source: FDA drug label (Cerezyme), Genzyme Corporation, effective August 27, 2026 (SPL set df60f030-866b-4374-a31f-8ae3f6b45c38), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Epinephrine | Imiglucerase | |
|---|---|---|
| Labeled for | Asthma | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $123.51 per unit 0.15 mg auto-injct | n/a |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once