What the FDA labels say about taking them together
Epinephrine and hyaluronidase
Hyaluronidase's FDA label of February 1, 2024 names epinephrine in its drug interactions section; the epinephrine labels PlainMeds reads (4) do not name hyaluronidase.
Check it at the source: the epinephrine FDA label on DailyMed (effective July 13, 2026, A-S Medication Solutions); the hyaluronidase FDA label on DailyMed (effective February 1, 2024, Amphastar Pharmaceuticals, Inc.).
What does the epinephrine label say about hyaluronidase?
Epinephrine's label (effective July 13, 2026) and its 3 other brand-application labels do not name hyaluronidase in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Epinephrine), A-S Medication Solutions, effective July 13, 2026 (SPL set 6e811e28-0199-4df7-a916-5940c632401d), via openFDA; the full label on DailyMed
What does the hyaluronidase label say about epinephrine?
Hyaluronidase label, drug interactionsWhen considering the administration of any other drug with hyaluronidase, it is recommended that appropriate references first be consulted to determine the usual precautions for the use of the other drug; e.g., when epinephrine is injected along with hyaluronidase, the precautions for the use of epinephrine in cardiovascular disease, thyroid disease, diabetes, digital nerve block, ischemia of the fingers and toes etc., should be observed.
Hylenex Recombinant label (Antares Pharma, Inc., November 11, 2024), drug interactionsAdmixture stability studies have shown that 2% lidocaine with 1:100,000 or 1:200,000 epinephrine is incompatible with hyaluronidase due to the presence of sodium metabisulfite, a common additive in anesthetic products containing epinephrine.
Source: FDA drug label (Hylenex Recombinant, BLA021859), Antares Pharma, Inc., effective November 11, 2024 (SPL set 3023cc56-ed4b-4e87-b3a1-81b20943f658), via openFDA
Source: FDA drug label (AMPHADASE), Amphastar Pharmaceuticals, Inc., effective February 1, 2024 (SPL set 8396ea96-7cb5-4e26-87a4-90bca9c3c6dd), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Epinephrine | Hyaluronidase | |
|---|---|---|
| Labeled for | Asthma | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $123.51 per unit 0.15 mg auto-injct | $53.69 per mL 150 units/mL vial |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once