What the FDA labels say about taking them together
Epinephrine and fentanyl
Fentanyl's FDA label of March 6, 2026 names epinephrine in its warnings and precautions section; the epinephrine labels PlainMeds reads (4) do not name fentanyl. The fentanyl label: “If volume expansion with fluids plus other countermeasures do not correct hypotension, consider administration of pressor agents other than epinephrine.”
Check it at the source: the epinephrine FDA label on DailyMed (effective July 13, 2026, A-S Medication Solutions); the fentanyl FDA label on DailyMed (effective March 6, 2026, Hikma Pharmaceuticals USA Inc.).
What does the epinephrine label say about fentanyl?
Epinephrine's label (effective July 13, 2026) and its 3 other brand-application labels do not name fentanyl in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Epinephrine), A-S Medication Solutions, effective July 13, 2026 (SPL set 6e811e28-0199-4df7-a916-5940c632401d), via openFDA; the full label on DailyMed
What does the fentanyl label say about epinephrine?
Fentanyl label, warnings and precautionsIf volume expansion with fluids plus other countermeasures do not correct hypotension, consider administration of pressor agents other than epinephrine.
Source: FDA drug label (Fentanyl Citrate), Hikma Pharmaceuticals USA Inc., effective March 6, 2026 (SPL set ce5db1c2-feb1-4ad2-847a-d02e865bd47e), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Epinephrine | Fentanyl | |
|---|---|---|
| Labeled for | Asthma | Pain |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $123.51 per unit 0.15 mg auto-injct | $1.79 per mL 100 mcg/2 mL vial |
| Shortage now | A presentation being discontinued | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once