What the FDA labels say about taking them together
Ephedrine and tolcapone
Tolcapone's FDA label of October 2, 2020 names ephedrine in its drug interactions section; the ephedrine labels PlainMeds reads (4) do not name tolcapone. The tolcapone label: “Drugs That Increase Catecholamines: Tolcapone did not influence the effect of ephedrine, an indirect sympathomimetic, on hemodynamic parameters or plasma catecholamine levels, either at rest or during exercise.”
Check it at the source: the ephedrine FDA label on DailyMed (effective September 16, 2024, Nexus Pharmaceuticals, LLC); the tolcapone FDA label on DailyMed (effective October 2, 2020, Bausch Health US LLC).
What does the ephedrine label say about tolcapone?
Ephedrine's label (effective September 16, 2024) and its 3 other brand-application labels do not name tolcapone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Emerphed PFS), Nexus Pharmaceuticals, LLC, effective September 16, 2024 (SPL set 14601778-93ac-43ec-b66b-5a942317133f), via openFDA; the full label on DailyMed
What does the tolcapone label say about ephedrine?
Tolcapone label, drug interactionsDrugs That Increase Catecholamines: Tolcapone did not influence the effect of ephedrine, an indirect sympathomimetic, on hemodynamic parameters or plasma catecholamine levels, either at rest or during exercise.
Source: FDA drug label (Tasmar), Bausch Health US LLC, effective October 2, 2020 (SPL set a0e47a9d-78e7-4523-983a-aa259f221736), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ephedrine | Tolcapone | |
|---|---|---|
| Labeled for | Asthma | Parkinson's disease |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once