What the FDA labels say about taking them together
Ephedrine and rocuronium
Ephedrine's FDA label of September 16, 2024 names rocuronium in its drug interactions section; the rocuronium labels PlainMeds reads (2) do not name ephedrine. The ephedrine label: “Ephedrine may reduce the onset time of neuromuscular blockade when used for intubation with rocuronium if administered simultaneously with anesthetic induction.”
Check it at the source: the ephedrine FDA label on DailyMed (effective September 16, 2024, Nexus Pharmaceuticals, LLC); the rocuronium FDA label on DailyMed (effective July 16, 2025, Fresenius Kabi USA, LLC).
What does the ephedrine label say about rocuronium?
Ephedrine label, drug interactionsRocuronium Clinical Impact: EMERPHED and EMERPHED-PFS may reduce the onset time of neuromuscular blockade when used for intubation with rocuronium if administered simultaneously with anesthetic induction. Intervention: Be aware of this potential interaction. No treatment or other interventions are needed.
Ephedrine Sulfate label (Par Health USA, LLC, March 17, 2026), drug interactionsRocuronium C linical Impact: Ephedrine may reduce the onset time of neuromuscular blockade when used for intubation with rocuronium if administered simultaneously with anesthetic induction.
Source: FDA drug label (Akovaz, NDA208289), Exela Pharma Sciences, LLC, effective November 27, 2020 (SPL set e92f3eda-33eb-4b34-9e8b-db8d32a5dbd9), via openFDA
Source: FDA drug label (Ephedrine Sulfate, NDA208943), Par Health USA, LLC, effective March 17, 2026 (SPL set 38723cb3-dfca-4c81-8c6f-63dd99929191), via openFDA
Source: FDA drug label (Emerphed PFS), Nexus Pharmaceuticals, LLC, effective September 16, 2024 (SPL set 14601778-93ac-43ec-b66b-5a942317133f), via openFDA; the full label on DailyMed
What does the rocuronium label say about ephedrine?
Rocuronium's label (effective July 16, 2025) and its 1 other brand-application label do not name ephedrine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Rocuronium), Fresenius Kabi USA, LLC, effective July 16, 2025 (SPL set 9a622308-7bda-4ca0-9de5-d6b3b4be3384), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ephedrine | Rocuronium | |
|---|---|---|
| Labeled for | Asthma | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once