What the FDA labels say about taking them together
Ephedrine and propofol
Ephedrine's FDA label of September 16, 2024 names propofol in its drug interactions section; the propofol label PlainMeds reads does not name ephedrine.
Check it at the source: the ephedrine FDA label on DailyMed (effective September 16, 2024, Nexus Pharmaceuticals, LLC); the propofol FDA label on DailyMed (effective September 11, 2025, Fresenius Kabi USA, LLC).
What does the ephedrine label say about propofol?
Ephedrine label, drug interactionsClonidine, propofol, monoamine oxidase inhibitors (MAOIs), atropine Clinical Impact: These drugs augment the pressor effect of ephedrine. Intervention: Carefully monitor the blood pressure of individuals who have received both EMERPHED and EMERPHED-PFS and any of these drugs.
Ephedrine Sulfate label (Par Health USA, LLC, March 17, 2026), drug interactionsClonidine, propofol, monoamine oxidase inhibitors (MAOIs), atropine C linical Impact: These drugs augment the pressor effect of ephedrine.
Source: FDA drug label (Akovaz, NDA208289), Exela Pharma Sciences, LLC, effective November 27, 2020 (SPL set e92f3eda-33eb-4b34-9e8b-db8d32a5dbd9), via openFDA
Source: FDA drug label (Ephedrine Sulfate, NDA208943), Par Health USA, LLC, effective March 17, 2026 (SPL set 38723cb3-dfca-4c81-8c6f-63dd99929191), via openFDA
Source: FDA drug label (Emerphed PFS), Nexus Pharmaceuticals, LLC, effective September 16, 2024 (SPL set 14601778-93ac-43ec-b66b-5a942317133f), via openFDA; the full label on DailyMed
What does the propofol label say about ephedrine?
Propofol's label (effective September 11, 2025) does not name ephedrine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Diprivan), Fresenius Kabi USA, LLC, effective September 11, 2025 (SPL set e3105799-a4b6-f3f4-e6e2-b2b29bbdb538), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ephedrine | Propofol | |
|---|---|---|
| Labeled for | Asthma | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.171 per mL 200 mg/20 mL vial |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once