What the FDA labels say about taking them together
Ephedrine and midodrine
Midodrine's FDA label of December 4, 2025 names ephedrine in its drug interactions section; the ephedrine labels PlainMeds reads (4) do not name midodrine. The midodrine label: “The risk of hypertension increases with concomitant administration of drugs that increase blood pressure.”
Check it at the source: the ephedrine FDA label on DailyMed (effective September 16, 2024, Nexus Pharmaceuticals, LLC); the midodrine FDA label on DailyMed (effective December 4, 2025, Novugen Pharma (USA) LLC).
What does the ephedrine label say about midodrine?
Ephedrine's label (effective September 16, 2024) and its 3 other brand-application labels do not name midodrine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Emerphed PFS), Nexus Pharmaceuticals, LLC, effective September 16, 2024 (SPL set 14601778-93ac-43ec-b66b-5a942317133f), via openFDA; the full label on DailyMed
What does the midodrine label say about ephedrine?
Midodrine label, drug interactionsThe risk of hypertension increases with concomitant administration of drugs that increase blood pressure (phenylephrine, pseudoephedrine, ephedrine, dihydroergotamine, thyroid hormones, or droxidopa).
Source: FDA drug label (Midodrine Hydrochloride), Novugen Pharma (USA) LLC, effective December 4, 2025 (SPL set 2bf011fe-d114-42a4-93e2-76a993a3ba34), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ephedrine | Midodrine | |
|---|---|---|
| Labeled for | Asthma | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.111 per tablet 5 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once