What the FDA labels say about taking them together
Ephedrine and methylergonovine
Ephedrine's FDA label of September 16, 2024 names methylergonovine in its drug interactions section; the methylergonovine label PlainMeds reads does not name ephedrine.
Check it at the source: the ephedrine FDA label on DailyMed (effective September 16, 2024, Nexus Pharmaceuticals, LLC); the methylergonovine FDA label on DailyMed (effective May 1, 2026, Teva Pharmaceuticals USA, Inc.).
What does the ephedrine label say about methylergonovine?
Ephedrine label, drug interactionsOxytocin and oxytocic drugs Clinical Impact: Serious postpartum hypertension has been described in patients who received both a vasopressor (…) and an oxytocic (…). Some of these patients experienced a stroke. Intervention: Carefully monitor the blood pressure of individuals who have received both EMERPHED and EMERPHED-PFS and an oxytocic.
Ephedrine label, warnings and precautionsEffect with Concomitant Oxytocic Drugs Serious postpartum hypertension has been described in patients who received both a vasopressor (i.e., methoxamine, phenylephrine, ephedrine) and an oxytocic (i.e., methylergonovine, ergonovine) [ see Drug Interactions ( 7 ) ].
Source: FDA drug label (Ephedrine Sulfate, NDA208943), Par Health USA, LLC, effective March 17, 2026 (SPL set 38723cb3-dfca-4c81-8c6f-63dd99929191), via openFDA
Source: FDA drug label (Emerphed PFS), Nexus Pharmaceuticals, LLC, effective September 16, 2024 (SPL set 14601778-93ac-43ec-b66b-5a942317133f), via openFDA; the full label on DailyMed
What does the methylergonovine label say about ephedrine?
Methylergonovine's label (effective May 1, 2026) does not name ephedrine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Methylergonovine Maleate), Teva Pharmaceuticals USA, Inc., effective May 1, 2026 (SPL set d8e4b8ed-3289-4611-8a61-2392a4bf6072), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ephedrine | Methylergonovine | |
|---|---|---|
| Labeled for | Asthma | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $4.50 per tablet 0.2 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once