What the FDA labels say about taking them together
Entacapone and epinephrine
Entacapone's FDA label of November 30, 2023 names epinephrine in its warnings section, and epinephrine's label names entacapone too. The epinephrine label: “… (MAO) inhibitors Catechol-O-methyl transferase (COMT) inhibitors, such as entacapone Clonidine Doxapram Oxytocin Drugs potentiating arrhythmogenic effects of epinephrine Patients who are concomitantly receiving any of …”
Check it at the source: the entacapone FDA label on DailyMed (effective November 30, 2023, Sandoz Inc); the epinephrine FDA label on DailyMed (effective July 13, 2026, A-S Medication Solutions).
What does the entacapone label say about epinephrine?
Entacapone label, warningsDrugs Metabolized By Catechol-O-Methyltransferase (COMT) When a single 400 mg dose of entacapone was given with intravenous isoprenaline (isoproterenol) and epinephrine without coadministered levodopa and dopa decarboxylase inhibitor, the overall mean maximal changes in heart rate during infusion were about 50% and 80% higher than with placebo, for isoprenaline and epinephrine, respectively.
Source: FDA drug label (Entacapone), NDA020796 (Orion Pharma), as published by Sandoz Inc, effective November 30, 2023 (SPL set ad4b6d79-efd3-4c43-b4dc-5afdacf939a4), via openFDA; the full label on DailyMed
What does the epinephrine label say about entacapone?
Adrenalin (Epinephrine In Sodium Chloride) label (Par Health USA, LLC, August 1, 2023), drug interactionsDrugs Potentiating Pressor Effects of Epinephrine Sympathomimetics β-blockers, such as propranolol Tricyclic anti-depressants Monoamine oxidase (MAO) inhibitors Catechol-O-methyl transferase (COMT) inhibitors, such as entacapone Clonidine Doxapram Oxytocin 7.3.
Epinephrine label (BPI Labs, LLC, December 26, 2025), drug interactionsDRUG INTERACTIONS Drugs antagonizing pressor effects of epinephrine α-blockers, such as phentolamine Vasodilators, such as nitrates Diuretics Antihypertensives Ergot alkaloids Drugs potentiating pressor effects of epinephrine Sympathomimetics β-blockers, such as propranolol Tricyclic anti-depressants Monoamine oxidase (MAO) inhibitors Catechol-O-methyl transferase (COMT) inhibitors, such as entacapone Clonidine Doxapram Oxytocin Drugs potentiating arrhythmogenic effects of epinephrine Patients who are concomitantly receiving any of the following drugs should be observed carefully for the development of cardiac arrhythmias [see Warnings and Precautions (5.6) and Adverse Reactions (6) ]. …
Source: FDA drug label (Adrenalin (Epinephrine In Sodium Chloride), NDA215875), Par Health USA, LLC, effective August 1, 2023 (SPL set 61b0e2a2-71ed-43d6-b1a7-36d2dae651b5), via openFDA
Source: FDA drug label (Epinephrine, NDA205029), BPI Labs, LLC, effective December 26, 2025 (SPL set db18519b-82a9-435b-85c7-a040d644f057), via openFDA
Source: FDA drug label (Epinephrine), A-S Medication Solutions, effective July 13, 2026 (SPL set 6e811e28-0199-4df7-a916-5940c632401d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Entacapone | Epinephrine | |
|---|---|---|
| Labeled for | Parkinson's disease | Asthma |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.325 per tablet 200 mg tablet | $123.51 per unit 0.15 mg auto-injct |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once