What the FDA labels say about taking them together
Ensitrelvir and voclosporin
Ensitrelvir's FDA label of June 3, 2026 names voclosporin in its drug interactions section; the voclosporin label PlainMeds reads does not name ensitrelvir. The ensitrelvir label: “Co-administration is contraindicated due to potential for acute and/or chronic nephrotoxicity.”
Check it at the source: the ensitrelvir FDA label on DailyMed (effective June 3, 2026, Shionogi Inc.); the voclosporin FDA label on DailyMed (effective August 25, 2026, Aurinia Pharma U.S., Inc.).
What does the ensitrelvir label say about voclosporin?
Ensitrelvir label, drug interactionsDrug Class: Immunosuppressants; Drug (s) within Class: voclosporin; Effect on Drug Concentration: ↑ voclosporin; Clinical Comment: Co-administration is contraindicated due to potential for acute and/or chronic nephrotoxicity.
Source: FDA drug label (XOCOVA), Shionogi Inc., effective June 3, 2026 (SPL set 526acf60-abc3-2cc2-e063-6294a90affa6), via openFDA; the full label on DailyMed
What does the voclosporin label say about ensitrelvir?
Voclosporin's label (effective August 25, 2026) does not name ensitrelvir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LUPKYNIS), Aurinia Pharma U.S., Inc., effective August 25, 2026 (SPL set 9f489295-1156-52c7-5fd0-5c4c52f9b813), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ensitrelvir | Voclosporin | |
|---|---|---|
| Labeled for | COVID-19 | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once