What the FDA labels say about taking them together
Ensitrelvir and triazolam
Ensitrelvir's FDA label of June 3, 2026 names triazolam in its drug interactions section; the triazolam label PlainMeds reads does not name ensitrelvir. The ensitrelvir label: “Co-administration is contraindicated.”
Check it at the source: the ensitrelvir FDA label on DailyMed (effective June 3, 2026, Shionogi Inc.); the triazolam FDA label on DailyMed (effective July 10, 2026, Mylan Pharmaceuticals Inc.).
What does the ensitrelvir label say about triazolam?
Ensitrelvir label, drug interactionsDrug Class: Sedatives; Drug (s) within Class: triazolam; Effect on Drug Concentration: ↑ triazolam; Clinical Comment: Co-administration is contraindicated.
Source: FDA drug label (XOCOVA), Shionogi Inc., effective June 3, 2026 (SPL set 526acf60-abc3-2cc2-e063-6294a90affa6), via openFDA; the full label on DailyMed
What does the triazolam label say about ensitrelvir?
Triazolam's label (effective July 10, 2026) does not name ensitrelvir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Triazolam), NDA017892 (Pfizer), as published by Mylan Pharmaceuticals Inc., effective July 10, 2026 (SPL set 5add318e-11b9-42f8-b052-0d8cebb32fcf), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ensitrelvir | Triazolam | |
|---|---|---|
| Labeled for | COVID-19 | Insomnia |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.308 per tablet 0.25 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once