What the FDA labels say about taking them together
Ensitrelvir and simvastatin
Ensitrelvir's FDA label of June 3, 2026 names simvastatin in its drug interactions section; the simvastatin label PlainMeds reads does not name ensitrelvir. The ensitrelvir label: “Co-administration is contraindicated. Discontinue use of simvastatin at least 12 hours prior to initiation of XOCOVA.”
Check it at the source: the ensitrelvir FDA label on DailyMed (effective June 3, 2026, Shionogi Inc.); the simvastatin FDA label on DailyMed (effective March 28, 2025, Organon LLC).
What does the ensitrelvir label say about simvastatin?
Ensitrelvir label, drug interactionsDrug Class: HMG-CoA reductase inhibitors (statins); Drug (s) within Class: simvastatin; Effect on Drug Concentration: ↑ simvastatin; Clinical Comment: Co-administration is contraindicated. Discontinue use of simvastatin at least 12 hours prior to initiation of XOCOVA.
Source: FDA drug label (XOCOVA), Shionogi Inc., effective June 3, 2026 (SPL set 526acf60-abc3-2cc2-e063-6294a90affa6), via openFDA; the full label on DailyMed
What does the simvastatin label say about ensitrelvir?
Simvastatin's label (effective March 28, 2025) does not name ensitrelvir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ZOCOR), Organon LLC, effective March 28, 2025 (SPL set 8f55d5de-5a4f-4a39-8c84-c53976dd6af9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ensitrelvir | Simvastatin | |
|---|---|---|
| Labeled for | COVID-19 | Heart attack and coronary artery disease, High cholesterol, High triglycerides |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.0321 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once