What the FDA labels say about taking them together
Ensitrelvir and pimozide
Ensitrelvir's FDA label of June 3, 2026 names pimozide in its drug interactions section; the pimozide label PlainMeds reads does not name ensitrelvir. The ensitrelvir label: “Co-administration is contraindicated due to serious and/or life-threatening reactions, such as cardiac arrhythmias.”
Check it at the source: the ensitrelvir FDA label on DailyMed (effective June 3, 2026, Shionogi Inc.); the pimozide FDA label on DailyMed (effective August 12, 2026, Par Health USA, LLC).
What does the ensitrelvir label say about pimozide?
Ensitrelvir label, drug interactionsDrug Class: Antipsychotics; Drug (s) within Class: lurasidone, pimozide; Effect on Drug Concentration: ↑ lurasidone, pimozide; Clinical Comment: Co-administration is contraindicated due to serious and/or life-threatening reactions, such as cardiac arrhythmias.
Source: FDA drug label (XOCOVA), Shionogi Inc., effective June 3, 2026 (SPL set 526acf60-abc3-2cc2-e063-6294a90affa6), via openFDA; the full label on DailyMed
What does the pimozide label say about ensitrelvir?
Pimozide's label (effective August 12, 2026) does not name ensitrelvir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Pimozide), Par Health USA, LLC, effective August 12, 2026 (SPL set 70b079e2-a1f7-4a93-8685-d60a4d7c1280), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ensitrelvir | Pimozide | |
|---|---|---|
| Labeled for | COVID-19 | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $1.23 per tablet 1 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once