What the FDA labels say about taking them together
Ensitrelvir and ivacaftor/lumacaftor
Ensitrelvir's FDA label of June 3, 2026 names ivacaftor/lumacaftor in its drug interactions section; the ivacaftor/lumacaftor label PlainMeds reads does not name ensitrelvir.
Check it at the source: the ensitrelvir FDA label on DailyMed (effective June 3, 2026, Shionogi Inc.); the ivacaftor/lumacaftor FDA label on DailyMed (effective March 24, 2026, Vertex Pharmaceuticals Incorporated).
What does the ensitrelvir label say about ivacaftor/lumacaftor?
Ensitrelvir label, drug interactionsNamed in a table that the FDA label file prints without its column breaks; the full label shows the table.
Source: FDA drug label (XOCOVA), Shionogi Inc., effective June 3, 2026 (SPL set 526acf60-abc3-2cc2-e063-6294a90affa6), via openFDA; the full label on DailyMed
What does the ivacaftor/lumacaftor label say about ensitrelvir?
Ivacaftor/lumacaftor's label (effective March 24, 2026) does not name ensitrelvir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ORKAMBI), Vertex Pharmaceuticals Incorporated, effective March 24, 2026 (SPL set 3fc1c40e-cfac-47a1-9e1a-61ead3570600), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ensitrelvir | Ivacaftor/lumacaftor | |
|---|---|---|
| Labeled for | COVID-19 | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once