What the FDA labels say about taking them together
Ensitrelvir and finerenone
Ensitrelvir's FDA label of June 3, 2026 names finerenone in its drug interactions section; the finerenone label PlainMeds reads does not name ensitrelvir. The ensitrelvir label: “Co-administration is contraindicated due to potential for serious adverse reactions, including hyperkalemia, hypotension, and hyponatremia.”
Check it at the source: the ensitrelvir FDA label on DailyMed (effective June 3, 2026, Shionogi Inc.); the finerenone FDA label on DailyMed (effective August 28, 2025, Bayer HealthCare Pharmaceuticals Inc.).
What does the ensitrelvir label say about finerenone?
Ensitrelvir label, drug interactionsDrug Class: Mineralocorticoid receptor antagonists; Drug (s) within Class: finerenone; Effect on Drug Concentration: ↑ finerenone; Clinical Comment: Co-administration is contraindicated due to potential for serious adverse reactions, including hyperkalemia, hypotension, and hyponatremia.
Source: FDA drug label (XOCOVA), Shionogi Inc., effective June 3, 2026 (SPL set 526acf60-abc3-2cc2-e063-6294a90affa6), via openFDA; the full label on DailyMed
What does the finerenone label say about ensitrelvir?
Finerenone's label (effective August 28, 2025) does not name ensitrelvir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Kerendia), Bayer HealthCare Pharmaceuticals Inc., effective August 28, 2025 (SPL set fc726765-5d5a-4d6e-b037-b847bda9fb7c), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ensitrelvir | Finerenone | |
|---|---|---|
| Labeled for | COVID-19 | Chronic kidney disease |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $22.86 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once