What the FDA labels say about taking them together
Enoxaparin and heparin
Enoxaparin's FDA label of May 28, 2026 names heparin in its contraindications section; the heparin labels PlainMeds reads (4) do not name enoxaparin. The enoxaparin label: “Monitor platelet count closely. Interchangeability with other heparins: Do not exchange with heparin or other LMWHs. Increased Risk of Thrombosis in Pregnant Women with Mechanical Prosthetic Heart Valves:”
Check it at the source: the enoxaparin FDA label on DailyMed (effective May 28, 2026, Sanofi-Aventis U.S. LLC); the heparin FDA label on DailyMed (effective November 28, 2025, Fresenius Kabi USA, LLC).
What does the enoxaparin label say about heparin?
Enoxaparin label, contraindicationsCONTRAINDICATIONS Lovenox is contraindicated in patients with: Active major bleeding History of immune-mediated heparin-induced thrombocytopenia (HIT) within the past 100 days or in the presence of circulating antibodies [see Warnings and Precautions (5.4) ] Known hypersensitivity to enoxaparin sodium (e.g., pruritus, urticaria, anaphylactic/anaphylactoid reactions) [see Adverse Reactions (6.2) ] Known hypersensitivity to heparin or pork products Known hypersensitivity to benzyl alcohol (which is in only the multiple-dose formulation of Lovenox) [see Warnings and Precautions (5.8) ] Active major bleeding ( 4 ) History of heparin-induced thrombocytopenia (HIT) within the past 100 days or in …
Enoxaparin label, warnings and precautionsMonitor platelet count closely. ( 5.5 ) Interchangeability with other heparins: Do not exchange with heparin or other LMWHs. ( 5.6 ) Increased Risk of Thrombosis in Pregnant Women with Mechanical Prosthetic Heart Valves:
Source: FDA drug label (Lovenox), Sanofi-Aventis U.S. LLC, effective May 28, 2026 (SPL set 5017a927-2a24-4f27-89f9-27c805bf7d59), via openFDA; the full label on DailyMed
What does the heparin label say about enoxaparin?
Heparin's label (effective November 28, 2025) and its 3 other brand-application labels do not name enoxaparin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Heparin Sodium), Fresenius Kabi USA, LLC, effective November 28, 2025 (SPL set d55b4a63-0c04-4874-b74f-9e9b9e8b008c), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Enoxaparin | Heparin | |
|---|---|---|
| Labeled for | Angina, Heart attack and coronary artery disease, Blood clots (DVT and PE) | Blood clots (DVT and PE), Atrial fibrillation |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $6.45 per mL 100 mg/mL syringe | $1.18 per mL 5,000 unit/mL vial |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once