What the FDA labels say about taking them together
Enalaprilat and triamterene
Enalaprilat's FDA label of June 7, 2024 names triamterene in its drug interactions section; triamterene's label does not name enalaprilat itself but warns about its class (ACE inhibitors). The enalaprilat label: “Potassium-sparing diuretics, potassium supplements, or potassium-containing salt substitutes may lead to significant increases in serum potassium.”
Check it at the source: the enalaprilat FDA label on DailyMed (effective June 7, 2024, Dr. Reddys Laboratories Inc); the triamterene FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.).
What does the enalaprilat label say about triamterene?
Enalaprilat label, drug interactionsPotassium-sparing diuretics (e.g., spironolactone, triamterene, or amiloride), potassium supplements, or potassium-containing salt substitutes may lead to significant increases in serum potassium.
Source: FDA drug label (Enalaprilat), Dr. Reddys Laboratories Inc, effective June 7, 2024 (SPL set 5d398da1-020c-ccb1-a775-ce8e0b29d621), via openFDA; the full label on DailyMed
What does the triamterene label say about enalaprilat?
Triamterene's label does not name enalaprilat itself; it warns about its class (ACE inhibitors):
Triamterene label, drug interactionsPotassium-sparing agents should be used with caution in conjunction with angiotensin-converting enzyme (ACE) inhibitors due to an increased risk of hyperkalemia.
Source: FDA drug label (Dyrenium), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set ebb177c0-d45d-4443-a85a-e76bd9931a42), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Enalaprilat | Triamterene | |
|---|---|---|
| Labeled for | High blood pressure | Heart failure, Edema (fluid retention) |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | $5.98 per capsule 50 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once