What the FDA labels say about taking them together
Enalaprilat and tenapanor
Tenapanor's FDA label of June 27, 2025 names enalaprilat in its drug interactions section; the enalaprilat label PlainMeds reads does not name tenapanor. The tenapanor label: “When enalapril was coadministered with tenapanor, the peak exposure (C max ) of enalapril and its active metabolite, enalaprilat, decreased by approximately 70% and total systemic exposures (AUC) decreased by …”
Check it at the source: the enalaprilat FDA label on DailyMed (effective June 7, 2024, Dr. Reddys Laboratories Inc); the tenapanor FDA label on DailyMed (effective June 27, 2025, Ardelyx, Inc.).
What does the enalaprilat label say about tenapanor?
Enalaprilat's label (effective June 7, 2024) does not name tenapanor in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Enalaprilat), Dr. Reddys Laboratories Inc, effective June 7, 2024 (SPL set 5d398da1-020c-ccb1-a775-ce8e0b29d621), via openFDA; the full label on DailyMed
What does the tenapanor label say about enalaprilat?
Tenapanor label, drug interactionsWhen enalapril was coadministered with XPHOZAH (30 mg twice daily for five days), the peak exposure (C max ) of enalapril and its active metabolite, enalaprilat, decreased by approximately 70% and total systemic exposures (AUC) decreased by 50 to 65% compared to when enalapril was administered alone [see Clinical Pharmacology (12.3) ].
Source: FDA drug label (Ibsrela, NDA211801), Ardelyx, Inc., effective May 28, 2025 (SPL set 2102da5f-a1a0-4ac7-a1f6-38698cf7273a), via openFDA
Source: FDA drug label (XPHOZAH 10 mg), Ardelyx, Inc., effective June 27, 2025 (SPL set c57e279c-0f1b-4238-81b7-4e0dc0cc60c5), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Enalaprilat | Tenapanor | |
|---|---|---|
| Labeled for | High blood pressure | Irritable bowel syndrome, Constipation |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | $32.54 per tablet 50 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once