What the FDA labels say about taking them together
Enalaprilat and indomethacin
Enalaprilat's FDA label of June 7, 2024 names indomethacin in its drug interactions section; indomethacin's label does not name enalaprilat itself but warns about its class (ACE inhibitors).
Check it at the source: the enalaprilat FDA label on DailyMed (effective June 7, 2024, Dr. Reddys Laboratories Inc); the indomethacin FDA label on DailyMed (effective December 19, 2025, Glenmark Pharmaceuticals Inc., USA).
What does the enalaprilat label say about indomethacin?
Enalaprilat label, drug interactionsIn a clinical pharmacology study, indomethacin or sulindac was administered to hypertensive patients receiving enalapril maleate.
Source: FDA drug label (Enalaprilat), Dr. Reddys Laboratories Inc, effective June 7, 2024 (SPL set 5d398da1-020c-ccb1-a775-ce8e0b29d621), via openFDA; the full label on DailyMed
What does the indomethacin label say about enalaprilat?
Indomethacin's label does not name enalaprilat itself; it warns about its class (ACE inhibitors):
Indomethacin label, drug interactionsNSAIDs may diminish the antihypertensive effect of angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), or beta-blockers (including propranolol).
Indomethacin label, drug interactionsNSAIDs may diminish the antihypertensive effect of angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), or beta-blockers (including propranolol). In patients who are elderly, volume-depleted (including those on diuretic therapy), or have renal impairment, co-administration of an NSAID with ACE inhibitors or ARBs may result in deterioration of renal function, including possible acute renal failure.
Source: FDA drug label (Indomethacin), Glenmark Pharmaceuticals Inc., USA, effective December 19, 2025 (SPL set f7ed39e2-5431-4e47-935c-c7441d058f94), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Enalaprilat | Indomethacin | |
|---|---|---|
| Labeled for | High blood pressure | Rheumatoid arthritis, Osteoarthritis |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | $0.210 per capsule 75 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once