What the FDA labels say about taking them together
Emtricitabine and nirmatrelvir/ritonavir
Nirmatrelvir/ritonavir's FDA label of February 19, 2026 names emtricitabine in its drug interactions section; the emtricitabine label PlainMeds reads does not name nirmatrelvir/ritonavir.
Check it at the source: the emtricitabine FDA label on DailyMed (effective December 2, 2025, Gilead Sciences, Inc.); the nirmatrelvir/ritonavir FDA label on DailyMed (effective February 19, 2026, Pfizer Laboratories Div Pfizer Inc).
What does the emtricitabine label say about nirmatrelvir/ritonavir?
Emtricitabine's label (effective December 2, 2025) does not name nirmatrelvir/ritonavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Emtriva), Gilead Sciences, Inc., effective December 2, 2025 (SPL set d6599395-3944-44f9-97f2-e0424c6b6a1f), via openFDA; the full label on DailyMed
What does the nirmatrelvir/ritonavir label say about emtricitabine?
Nirmatrelvir/ritonavir label, drug interactionsDrug Class: Anti-HIV; Drugs within Class: efavirenz, maraviroc, nevirapine, zidovudine, bictegravir/ emtricitabine/ tenofovir; Effect on Concentration: ↑ efavirenz ↑ maraviroc ↑ nevirapine ↓ zidovudine ↑ bictegravir ↔ emtricitabine ↑ tenofovir; Clinical Comments: For further information, refer to the respective anti-HIV drugs prescribing information.
Source: FDA drug label (Paxlovid), Pfizer Laboratories Div Pfizer Inc, effective February 19, 2026 (SPL set 8a99d6d6-fd9e-45bb-b1bf-48c7f761232a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Emtricitabine | Nirmatrelvir/ritonavir | |
|---|---|---|
| Labeled for | HIV | COVID-19 |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $12.69 per capsule 200 mg capsule | $49.24 per unit 300-100 mg dose pack |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once