What the FDA labels say about taking them together
Eltrombopag and topotecan
Eltrombopag's FDA label of December 18, 2025 names topotecan in its drug interactions section; the topotecan labels PlainMeds reads (3) do not name eltrombopag.
Check it at the source: the eltrombopag FDA label on DailyMed (effective December 18, 2025, Novartis Pharmaceuticals Corporation); the topotecan FDA label on DailyMed (effective July 7, 2022, Novartis Pharmaceuticals Corporation).
What does the eltrombopag label say about topotecan?
Eltrombopag label, drug interactionsUse caution when concomitantly administering PROMACTA and drugs that are substrates of OATP1B1 (e.g., atorvastatin, bosentan, ezetimibe, fluvastatin, glyburide, olmesartan, pitavastatin, pravastatin, rosuvastatin, repaglinide, rifampin, simvastatin acid, SN-38 [active metabolite of irinotecan], valsartan) or breast cancer resistance protein (BCRP) (e.g., imatinib, irinotecan, lapatinib, methotrexate, mitoxantrone, rosuvastatin, sulfasalazine, topotecan).
Source: FDA drug label (Alvaiz, NDA216774), Teva Pharmaceuticals, Inc., effective January 1, 2026 (SPL set ed51e463-7a03-4858-bbd2-882ce4753d5a), via openFDA
Source: FDA drug label (PROMACTA), Novartis Pharmaceuticals Corporation, effective December 18, 2025 (SPL set 7714a0ed-34bb-46e6-a0a5-b363908b22c2), via openFDA; the full label on DailyMed
What does the topotecan label say about eltrombopag?
Topotecan's label (effective July 7, 2022) and its 2 other brand-application labels do not name eltrombopag in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (HYCAMTIN), NDA020671 (Sandoz), as published by Novartis Pharmaceuticals Corporation, effective July 7, 2022 (SPL set eeee060c-a9ec-423e-a374-8484009f8524), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Eltrombopag | Topotecan | |
|---|---|---|
| Labeled for | Anemia | Lung cancer |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $25.85 per tablet 50 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once