What the FDA labels say about taking them together
Elexacaftor/ivacaftor/tezacaftor and sirolimus
Elexacaftor/ivacaftor/tezacaftor's FDA label of June 22, 2026 names sirolimus in its drug interactions section; the sirolimus labels PlainMeds reads (4) do not name elexacaftor/ivacaftor/tezacaftor. The elexacaftor/ivacaftor/tezacaftor label: “When used concomitantly with digoxin or other substrates of P-gp with a narrow therapeutic index such as cyclosporine, everolimus, sirolimus and tacrolimus, caution and appropriate monitoring should be used.”
Check it at the source: the elexacaftor/ivacaftor/tezacaftor FDA label on DailyMed (effective June 22, 2026); the sirolimus FDA label on DailyMed (effective January 28, 2026, Glenmark Pharmaceuticals Inc., USA).
What does the elexacaftor/ivacaftor/tezacaftor label say about sirolimus?
Elexacaftor/ivacaftor/tezacaftor label, drug interactionsWhen used concomitantly with digoxin or other substrates of P-gp with a narrow therapeutic index such as cyclosporine, everolimus, sirolimus and tacrolimus, caution and appropriate monitoring should be used [see Clinical Pharmacology (12.3) ].
Source: FDA drug label (Trikafta), Vertex Pharmaceuticals Incorporated, effective June 22, 2026 (SPL set f354423a-85c2-41c3-a9db-0f3aee135d8d), via openFDA; the full label on DailyMed
What does the sirolimus label say about elexacaftor/ivacaftor/tezacaftor?
Sirolimus's label (effective January 28, 2026) and its 3 other brand-application labels do not name elexacaftor/ivacaftor/tezacaftor in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (sirolimus), Glenmark Pharmaceuticals Inc., USA, effective January 28, 2026 (SPL set 57fb4d90-3ccb-4a69-af1e-53be83f7a504), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Elexacaftor/ivacaftor/tezacaftor | Sirolimus | |
|---|---|---|
| Labeled for | n/a | Organ transplant rejection |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | $0.723 per tablet 1 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once