What the FDA labels say about taking them together
Elexacaftor/ivacaftor/tezacaftor and repaglinide
Elexacaftor/ivacaftor/tezacaftor's FDA label of June 22, 2026 names repaglinide in its drug interactions section; the repaglinide label PlainMeds reads does not name elexacaftor/ivacaftor/tezacaftor. The elexacaftor/ivacaftor/tezacaftor label: “Concomitant use of TRIKAFTA may increase exposures of medicinal products that are substrates of these transporters, such as statins, glyburide, nateglinide and repaglinide.”
Check it at the source: the elexacaftor/ivacaftor/tezacaftor FDA label on DailyMed (effective June 22, 2026); the repaglinide FDA label on DailyMed (effective May 2, 2025, Chartwell RX, LLC).
What does the elexacaftor/ivacaftor/tezacaftor label say about repaglinide?
Elexacaftor/ivacaftor/tezacaftor label, drug interactionsConcomitant use of TRIKAFTA may increase exposures of medicinal products that are substrates of these transporters, such as statins, glyburide, nateglinide and repaglinide.
Source: FDA drug label (Trikafta), Vertex Pharmaceuticals Incorporated, effective June 22, 2026 (SPL set f354423a-85c2-41c3-a9db-0f3aee135d8d), via openFDA; the full label on DailyMed
What does the repaglinide label say about elexacaftor/ivacaftor/tezacaftor?
Repaglinide's label (effective May 2, 2025) does not name elexacaftor/ivacaftor/tezacaftor in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Repaglinide), Chartwell RX, LLC, effective May 2, 2025 (SPL set cb995e92-295e-4638-a064-978211f5afe1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Elexacaftor/ivacaftor/tezacaftor | Repaglinide | |
|---|---|---|
| Labeled for | n/a | Type 2 diabetes |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | $0.0987 per tablet 1 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once