What the FDA labels say about taking them together
Elexacaftor/ivacaftor/tezacaftor and nirmatrelvir/ritonavir
Nirmatrelvir/ritonavir's FDA label of February 19, 2026 names elexacaftor/ivacaftor/tezacaftor in its drug interactions section; the elexacaftor/ivacaftor/tezacaftor label PlainMeds reads does not name nirmatrelvir/ritonavir. The nirmatrelvir/ritonavir label: “Cystic fibrosis transmembrane conductance regulator potentiators ivacaftor elexacaftor/tezacaftor/ ivacaftor tezacaftor/ivacaftor ↑ ivacaftor ↑ elexacaftor/tezacaftor/ ivacaftor ↑ tezacaftor/ivacaftor Reduce dosage when …”
Check it at the source: the elexacaftor/ivacaftor/tezacaftor FDA label on DailyMed (effective June 22, 2026); the nirmatrelvir/ritonavir FDA label on DailyMed (effective February 19, 2026, Pfizer Laboratories Div Pfizer Inc).
What does the elexacaftor/ivacaftor/tezacaftor label say about nirmatrelvir/ritonavir?
Elexacaftor/ivacaftor/tezacaftor's label (effective June 22, 2026) does not name nirmatrelvir/ritonavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Trikafta), Vertex Pharmaceuticals Incorporated, effective June 22, 2026 (SPL set f354423a-85c2-41c3-a9db-0f3aee135d8d), via openFDA; the full label on DailyMed
What does the nirmatrelvir/ritonavir label say about elexacaftor/ivacaftor/tezacaftor?
Nirmatrelvir/ritonavir label, drug interactionsCystic fibrosis transmembrane conductance regulator potentiators ivacaftor elexacaftor/tezacaftor/ ivacaftor tezacaftor/ivacaftor ↑ ivacaftor ↑ elexacaftor/tezacaftor/ ivacaftor ↑ tezacaftor/ivacaftor Reduce dosage when co-administered with PAXLOVID.
Source: FDA drug label (Paxlovid), Pfizer Laboratories Div Pfizer Inc, effective February 19, 2026 (SPL set 8a99d6d6-fd9e-45bb-b1bf-48c7f761232a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Elexacaftor/ivacaftor/tezacaftor | Nirmatrelvir/ritonavir | |
|---|---|---|
| Labeled for | n/a | COVID-19 |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | $49.24 per unit 300-100 mg dose pack |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once