What the FDA labels say about taking them together
Elexacaftor/ivacaftor/tezacaftor and everolimus
Elexacaftor/ivacaftor/tezacaftor's FDA label of June 22, 2026 names everolimus in its drug interactions section; the everolimus labels PlainMeds reads (2) do not name elexacaftor/ivacaftor/tezacaftor. The elexacaftor/ivacaftor/tezacaftor label: “When used concomitantly with digoxin or other substrates of P-gp with a narrow therapeutic index such as cyclosporine, everolimus, sirolimus and tacrolimus, caution and appropriate monitoring should be used.”
Check it at the source: the elexacaftor/ivacaftor/tezacaftor FDA label on DailyMed (effective June 22, 2026); the everolimus FDA label on DailyMed (effective June 1, 2026, Novartis Pharmaceuticals Corporation).
What does the elexacaftor/ivacaftor/tezacaftor label say about everolimus?
Elexacaftor/ivacaftor/tezacaftor label, drug interactionsWhen used concomitantly with digoxin or other substrates of P-gp with a narrow therapeutic index such as cyclosporine, everolimus, sirolimus and tacrolimus, caution and appropriate monitoring should be used [see Clinical Pharmacology (12.3) ].
Source: FDA drug label (Trikafta), Vertex Pharmaceuticals Incorporated, effective June 22, 2026 (SPL set f354423a-85c2-41c3-a9db-0f3aee135d8d), via openFDA; the full label on DailyMed
What does the everolimus label say about elexacaftor/ivacaftor/tezacaftor?
Everolimus's label (effective June 1, 2026) and its 1 other brand-application label do not name elexacaftor/ivacaftor/tezacaftor in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Afinitor), Novartis Pharmaceuticals Corporation, effective June 1, 2026 (SPL set 2150f73a-179b-4afc-b8ce-67c85cc72f04), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Elexacaftor/ivacaftor/tezacaftor | Everolimus | |
|---|---|---|
| Labeled for | n/a | Breast cancer, Seizures and epilepsy, Organ transplant rejection |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | $26.32 per tablet 10 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once