What the FDA labels say about taking them together
Eletriptan and nirmatrelvir/ritonavir
Nirmatrelvir/ritonavir's FDA label of February 19, 2026 names eletriptan in its contraindications section; the eletriptan labels PlainMeds reads (2) do not name nirmatrelvir/ritonavir. The nirmatrelvir/ritonavir label: “Co-administration of eletriptan within at least 72 hours of PAXLOVID is contraindicated due to potential for serious adverse reactions including cardiovascular and cerebrovascular events.”
Check it at the source: the eletriptan FDA label on DailyMed (effective November 27, 2024, Teva Pharmaceuticals USA, Inc.); the nirmatrelvir/ritonavir FDA label on DailyMed (effective February 19, 2026, Pfizer Laboratories Div Pfizer Inc).
What does the eletriptan label say about nirmatrelvir/ritonavir?
Eletriptan's label (effective November 27, 2024) and its 1 other brand-application label do not name nirmatrelvir/ritonavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Eletriptan Hydrobromide), Teva Pharmaceuticals USA, Inc., effective November 27, 2024 (SPL set 62dc12ce-4f19-41c6-9593-3cae29f04af1), via openFDA; the full label on DailyMed
What does the nirmatrelvir/ritonavir label say about eletriptan?
Nirmatrelvir/ritonavir label, contraindicationsMigraine medications: eletriptan, ubrogepant
Nirmatrelvir/ritonavir label, drug interactionsDrug Class: Migraine medications; Drugs within Class: eletriptan; Effect on Concentration: ↑ eletriptan; Clinical Comments: Co-administration of eletriptan within at least 72 hours of PAXLOVID is contraindicated due to potential for serious adverse reactions including cardiovascular and cerebrovascular events [see ].
Source: FDA drug label (Paxlovid), Pfizer Laboratories Div Pfizer Inc, effective February 19, 2026 (SPL set 8a99d6d6-fd9e-45bb-b1bf-48c7f761232a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Eletriptan | Nirmatrelvir/ritonavir | |
|---|---|---|
| Labeled for | Migraine | COVID-19 |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $1.75 per tablet 40 mg tablet | $49.24 per unit 300-100 mg dose pack |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once