What the FDA labels say about taking them together
Eletriptan and itraconazole
Eletriptan's FDA label of November 27, 2024 names itraconazole in its contraindications section, and itraconazole's label names eletriptan too. The itraconazole label: “Antimigraine Drugs Ergot alkaloids Contraindicated during and 2 weeks after TOLSURA treatment. Eletriptan Monitor for adverse reactions.”
Check it at the source: the eletriptan FDA label on DailyMed (effective November 27, 2024, Teva Pharmaceuticals USA, Inc.); the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.).
What does the eletriptan label say about itraconazole?
Eletriptan label, contraindicationsRecent use (i.e., within at least 72 hours) of the following potent CYP3A4 inhibitors: ketoconazole, itraconazole, nefazodone, troleandomycin, clarithromycin, ritonavir, or nelfinavir [see Drug Interactions (7.2) and Clinical Pharmacology ( 12.3 )].
Source: FDA drug label (Eletriptan Hydrobromide), Teva Pharmaceuticals USA, Inc., effective November 27, 2024 (SPL set 62dc12ce-4f19-41c6-9593-3cae29f04af1), via openFDA; the full label on DailyMed
What does the itraconazole label say about eletriptan?
Itraconazole label, drug interactionsAntimigraine Drugs Ergot alkaloids (e.g., dihydroergotamine, ergotamine) Contraindicated during and 2 weeks after SPORANOX ® treatment. Eletriptan Monitor for adverse reactions.
Source: FDA drug label (Tolsura, NDA208901), Mayne Pharma Commercial LLC, effective April 23, 2025 (SPL set 306352d1-9d5a-49ad-b72d-893b99546861), via openFDA
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Eletriptan | Itraconazole | |
|---|---|---|
| Labeled for | Migraine | Fungal infections |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $1.75 per tablet 40 mg tablet | $0.910 per capsule 100 mg capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once