What the FDA labels say about taking them together
Elbasvir/grazoprevir and simvastatin
Elbasvir/grazoprevir's FDA label of March 13, 2026 names simvastatin in its drug interactions section; the simvastatin label PlainMeds reads does not name elbasvir/grazoprevir. The elbasvir/grazoprevir label: “Statin-associated adverse events such as myopathy should be closely monitored. The lowest necessary dose should be used when co-administered with ZEPATIER.”
Check it at the source: the elbasvir/grazoprevir FDA label on DailyMed (effective March 13, 2026, Merck Sharp & Dohme LLC); the simvastatin FDA label on DailyMed (effective March 28, 2025, Organon LLC).
What does the elbasvir/grazoprevir label say about simvastatin?
Elbasvir/grazoprevir label, drug interactionsConcomitant Drug Class/Drug Name: Fluvastatin Lovastatin Simvastatin; Effect on Concentration ↓ = decrease, ↑ = increase: ↑ fluvastatin ↑ lovastatin ↑ simvastatin; Clinical Comment: Statin-associated adverse events such as myopathy should be closely monitored. The lowest necessary dose should be used when co-administered with ZEPATIER.
Source: FDA drug label (ZEPATIER), Merck Sharp & Dohme LLC, effective March 13, 2026 (SPL set 164dc02a-9180-426a-b8b5-04ab39d2bbd4), via openFDA; the full label on DailyMed
What does the simvastatin label say about elbasvir/grazoprevir?
Simvastatin's label (effective March 28, 2025) does not name elbasvir/grazoprevir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ZOCOR), Organon LLC, effective March 28, 2025 (SPL set 8f55d5de-5a4f-4a39-8c84-c53976dd6af9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Elbasvir/grazoprevir | Simvastatin | |
|---|---|---|
| Labeled for | Hepatitis C | Heart attack and coronary artery disease, High cholesterol, High triglycerides |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | $0.0321 per tablet 20 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once