What the FDA labels say about taking them together
Elbasvir/grazoprevir and rosuvastatin
Elbasvir/grazoprevir's FDA label of March 13, 2026 names rosuvastatin in its drug interactions section, and rosuvastatin's label names elbasvir/grazoprevir too. The elbasvir/grazoprevir label: “The dose of rosuvastatin should not exceed a daily dose of 10 mg when co-administered with ZEPATIER.”
Check it at the source: the elbasvir/grazoprevir FDA label on DailyMed (effective March 13, 2026, Merck Sharp & Dohme LLC); the rosuvastatin FDA label on DailyMed (effective September 4, 2026, ScieGen Pharmaceuticals, Inc.).
What does the elbasvir/grazoprevir label say about rosuvastatin?
Elbasvir/grazoprevir label, drug interactionsConcomitant Drug Class/Drug Name: Rosuvastatin; Effect on Concentration ↓ = decrease, ↑ = increase: ↑ rosuvastatin; Clinical Comment: The dose of rosuvastatin should not exceed a daily dose of 10 mg when co-administered with ZEPATIER.
Source: FDA drug label (ZEPATIER), Merck Sharp & Dohme LLC, effective March 13, 2026 (SPL set 164dc02a-9180-426a-b8b5-04ab39d2bbd4), via openFDA; the full label on DailyMed
What does the rosuvastatin label say about elbasvir/grazoprevir?
Rosuvastatin label, drug interactionsAdditional Anti-Viral Medications Prevention or Management: Simeprevir Dasabuvir/ombitasvir/paritaprevir/ritonavir Elbasvir/grazoprevir Sofosbuvir/velpatasvir Glecaprevir/pibrentasvir Atazanavir/ritonavir Lopinavir/ritonavir Initiate with rosuvastatin 5 mg once daily, and do not exceed a dosage of rosuvastatin 10 mg once daily.
Crestor label (AstraZeneca Pharmaceuticals LP, April 29, 2026), drug interactionsElbasvir/grazoprevir
Source: FDA drug label (Crestor, NDA021366), AstraZeneca Pharmaceuticals LP, effective April 29, 2026 (SPL set 325a5d0e-9a72-4015-9fcd-1655fb504cee), via openFDA
Source: FDA drug label (Rosuvastatin), ScieGen Pharmaceuticals, Inc., effective September 4, 2026 (SPL set ee4933c5-0d97-494d-ac0f-2083e0100836), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Elbasvir/grazoprevir | Rosuvastatin | |
|---|---|---|
| Labeled for | Hepatitis C | Heart attack and coronary artery disease, High cholesterol, High triglycerides, Stroke prevention |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | $0.0692 per tablet 40 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once