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What the FDA labels say about taking them together

Elbasvir/grazoprevir and rifampin

Elbasvir/grazoprevir's FDA label of March 13, 2026 names rifampin in its contraindications section; the rifampin label PlainMeds reads does not name elbasvir/grazoprevir.

Check it at the source: the elbasvir/grazoprevir FDA label on DailyMed (effective March 13, 2026, Merck Sharp & Dohme LLC); the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.).

What does the elbasvir/grazoprevir label say about rifampin?

Elbasvir/grazoprevir label, contraindications

Named in a table that the FDA label file prints without its column breaks; the full label shows the table.

Source: FDA drug label (ZEPATIER), Merck Sharp & Dohme LLC, effective March 13, 2026 (SPL set 164dc02a-9180-426a-b8b5-04ab39d2bbd4), via openFDA; the full label on DailyMed

What does the rifampin label say about elbasvir/grazoprevir?

Rifampin's label (effective February 11, 2026) does not name elbasvir/grazoprevir in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

0Elbasvir/grazoprevir generic labelers
13Rifampin generic labelers
Elbasvir/grazoprevirRifampin
Labeled forHepatitis Cn/a
Boxed warningYesNo
Pharmacy cost (NADAC)n/a$0.679 per capsule 300 mg capsule
Shortage nowA presentation being discontinuedIn shortage

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?