What the FDA labels say about taking them together
Elbasvir/grazoprevir and modafinil
Elbasvir/grazoprevir's FDA label of March 13, 2026 names modafinil in its drug interactions section; the modafinil label PlainMeds reads does not name elbasvir/grazoprevir. The elbasvir/grazoprevir label: “Co-administration of ZEPATIER with modafinil may lead to reduced therapeutic effect of ZEPATIER. Co-administration is not recommended.”
Check it at the source: the elbasvir/grazoprevir FDA label on DailyMed (effective March 13, 2026, Merck Sharp & Dohme LLC); the modafinil FDA label on DailyMed (effective October 16, 2025, Golden State Medical Supply, Inc.).
What does the elbasvir/grazoprevir label say about modafinil?
Elbasvir/grazoprevir label, drug interactionsConcomitant Drug Class/Drug Name: Wakefulness-Promoting Agents: Modafinil; Effect on Concentration ↓ = decrease, ↑ = increase: ↓ EBR ↓ GZR; Clinical Comment: Co-administration of ZEPATIER with modafinil may lead to reduced therapeutic effect of ZEPATIER. Co-administration is not recommended.
Source: FDA drug label (ZEPATIER), Merck Sharp & Dohme LLC, effective March 13, 2026 (SPL set 164dc02a-9180-426a-b8b5-04ab39d2bbd4), via openFDA; the full label on DailyMed
What does the modafinil label say about elbasvir/grazoprevir?
Modafinil's label (effective October 16, 2025) does not name elbasvir/grazoprevir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Provigil), NDA020717 (Nuvo Pharms), as published by Golden State Medical Supply, Inc., effective October 16, 2025 (SPL set 3b8d1c32-dac9-50e6-e063-6394a90aa5a5), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Elbasvir/grazoprevir | Modafinil | |
|---|---|---|
| Labeled for | Hepatitis C | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | $0.344 per tablet 200 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once