What the FDA labels say about taking them together
Elbasvir/grazoprevir and ketoconazole
Elbasvir/grazoprevir's FDA label of March 13, 2026 names ketoconazole in its drug interactions section; the ketoconazole label PlainMeds reads does not name elbasvir/grazoprevir. The elbasvir/grazoprevir label: “Co-administration of oral ketoconazole is not recommended.”
Check it at the source: the elbasvir/grazoprevir FDA label on DailyMed (effective March 13, 2026, Merck Sharp & Dohme LLC); the ketoconazole FDA label on DailyMed (effective January 28, 2026, E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC).
What does the elbasvir/grazoprevir label say about ketoconazole?
Elbasvir/grazoprevir label, drug interactionsConcomitant Drug Class/Drug Name: Antifungals: oral Ketoconazole These interactions have been studied in healthy adults.; Effect on Concentration ↓ = decrease, ↑ = increase: ↑ EBR ↑ GZR; Clinical Comment: Co-administration of oral ketoconazole is not recommended.
Source: FDA drug label (ZEPATIER), Merck Sharp & Dohme LLC, effective March 13, 2026 (SPL set 164dc02a-9180-426a-b8b5-04ab39d2bbd4), via openFDA; the full label on DailyMed
What does the ketoconazole label say about elbasvir/grazoprevir?
Ketoconazole's label (effective January 28, 2026) does not name elbasvir/grazoprevir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ketoconazole), E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC, effective January 28, 2026 (SPL set cad7c647-34a9-4e4e-83b3-8d78e58f588f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Elbasvir/grazoprevir | Ketoconazole | |
|---|---|---|
| Labeled for | Hepatitis C | Fungal infections |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | $0.249 per gram 2% cream |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once