What the FDA labels say about taking them together
Elbasvir/grazoprevir and itraconazole
Itraconazole's FDA label of July 13, 2026 names elbasvir/grazoprevir in its drug interactions section; the elbasvir/grazoprevir label PlainMeds reads does not name itraconazole. The itraconazole label: “Elbasvir/grazoprevir Not recommended during and 2 weeks after SPORANOX ® treatment. Glecaprevir/pibrentasvir Monitor for adverse reactions. Tenofovir disoproxil fumarate Monitor for adverse reactions. …”
Check it at the source: the elbasvir/grazoprevir FDA label on DailyMed (effective March 13, 2026, Merck Sharp & Dohme LLC); the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.).
What does the elbasvir/grazoprevir label say about itraconazole?
Elbasvir/grazoprevir's label (effective March 13, 2026) does not name itraconazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ZEPATIER), Merck Sharp & Dohme LLC, effective March 13, 2026 (SPL set 164dc02a-9180-426a-b8b5-04ab39d2bbd4), via openFDA; the full label on DailyMed
What does the itraconazole label say about elbasvir/grazoprevir?
Itraconazole label, drug interactionsElbasvir/grazoprevir Not recommended during and 2 weeks after SPORANOX ® treatment. Glecaprevir/pibrentasvir Monitor for adverse reactions. Tenofovir disoproxil fumarate Monitor for adverse reactions. Beta Blockers Nadolol Monitor for adverse reactions.
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Elbasvir/grazoprevir | Itraconazole | |
|---|---|---|
| Labeled for | Hepatitis C | Fungal infections |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | $0.910 per capsule 100 mg capsule |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once