What the FDA labels say about taking them together
Elbasvir/grazoprevir and etravirine
Elbasvir/grazoprevir's FDA label of March 13, 2026 names etravirine in its drug interactions section, and etravirine's label names elbasvir/grazoprevir too. The elbasvir/grazoprevir label: “Co-administration of ZEPATIER with etravirine may lead to reduced therapeutic effect of ZEPATIER. Co-administration is not recommended.”
Check it at the source: the elbasvir/grazoprevir FDA label on DailyMed (effective March 13, 2026, Merck Sharp & Dohme LLC); the etravirine FDA label on DailyMed (effective August 15, 2023, Janssen Products LP).
What does the elbasvir/grazoprevir label say about etravirine?
Elbasvir/grazoprevir label, drug interactionsConcomitant Drug Class/Drug Name: Etravirine; Effect on Concentration ↓ = decrease, ↑ = increase: ↓ EBR ↓ GZR; Clinical Comment: Co-administration of ZEPATIER with etravirine may lead to reduced therapeutic effect of ZEPATIER. Co-administration is not recommended.
Source: FDA drug label (ZEPATIER), Merck Sharp & Dohme LLC, effective March 13, 2026 (SPL set 164dc02a-9180-426a-b8b5-04ab39d2bbd4), via openFDA; the full label on DailyMed
What does the etravirine label say about elbasvir/grazoprevir?
Etravirine label, drug interactionsIncrease the daclatasvir dose to 90 mg once daily. elbasvir/grazoprevir ↓ elbasvir ↓ grazoprevir Co-administration of INTELENCE with elbasvir/grazoprevir may decrease elbasvir and grazoprevir concentrations, leading to reduced therapeutic effect of elbasvir/grazoprevir.
Source: FDA drug label (Intelence), Janssen Products LP, effective August 15, 2023 (SPL set 6a9cbc29-9f15-4b24-8d86-206b82887f3d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Elbasvir/grazoprevir | Etravirine | |
|---|---|---|
| Labeled for | Hepatitis C | HIV |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | $9.94 per tablet 200 mg tablet |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once