What the FDA labels say about taking them together
Elagolix and norethindrone
Elagolix's FDA label of December 19, 2025 names norethindrone in its warnings and precautions section; the norethindrone labels PlainMeds reads (2) do not name elagolix. The elagolix label: “Co-administration of ORILISSA with COCs containing norethindrone acetate did not show reduction in plasma concentrations of norethindrone.”
Check it at the source: the elagolix FDA label on DailyMed (effective December 19, 2025, AbbVie Inc.); the norethindrone FDA label on DailyMed (effective January 31, 2026, Glenmark Pharmaceuticals Inc., USA).
What does the elagolix label say about norethindrone?
Elagolix label, warnings and precautionsCo-administration of ORILISSA with COCs containing norethindrone acetate did not show reduction in plasma concentrations of norethindrone [see Drug Interactions ( 7.1 ), Clinical Pharmacology ( 12.3 )].
Source: FDA drug label (Orilissa), AbbVie Inc., effective December 19, 2025 (SPL set a86757b3-09c5-fd3b-1223-244e94f50a66), via openFDA; the full label on DailyMed
What does the norethindrone label say about elagolix?
Norethindrone's label (effective January 31, 2026) and its 1 other brand-application label do not name elagolix in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Norethindrone), Glenmark Pharmaceuticals Inc., USA, effective January 31, 2026 (SPL set 0d2f8fea-3675-40d2-afd9-9fcb148dbd4b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Elagolix | Norethindrone | |
|---|---|---|
| Labeled for | n/a | Birth control |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $43.81 per tablet 150 mg tablet | $0.290 per tablet 5 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once